# How To Play Pocket Sixes (66) In Texas Hold'em

> Source: [Pocket Sixes (66) Strategy Guide on Smarter.Poker](https://smarter.poker/learn/hands/pocket-sixes)

## Executive Answer Summary
Pocket Sixes (66) Holds 63.3% Equity Against A Random Hand And Opens At High Frequency Across All 6-Max Positions, Excelling At Set-Mining And Blocking Wheel Straight Completions.

## Combinatoric Fact Sheet
- **Hand Notation**: `66`
- **Common Nickname**: Route 66
- **Hand Category**: Small-To-Medium Pocket Pair
- **Deck Combinations**: 6 Out Of 1,326 (0.45% (220 To 1 Against))
- **Preflop Rank**: 23 Of 169
- **Equity Vs. Random Hand**: 63.3%

## 6-Max 100BB GTO Opening Strategy By Position
| Position | Recommended Action |
| :--- | :--- |
| UTG | 75% Mixed Open Raise |
| HJ | 100% Open Raise |
| CO | 100% Open Raise |
| BTN | 100% Open Raise |
| SB | 100% Open Raise |

## Facing A 3-Bet & Postflop Playbook
- **Facing A 3-Bet**: Call In Position With Deep Implied Odds; Fold Out Of Position At 100BB.
- **Postflop Execution**: Look To Flop Sets Or Open-Ended Straight Draws On Low Runouts (5-4-3, 6-5-2) And Check-Fold Unimproved On Heavy Broadway Textures.

## Head-To-Head Preflop Equity Matchups
| Villain Hand | Hero Equity | Villain Equity | Tie % |
| :--- | :--- | :--- | :--- |
| AKs (Ace-King Suited) | 52.2% | 47.4% | 0.4% |
| 55 (Pocket Fives) | 81.2% | 18.3% | 0.5% |
| A5s (Ace-Five Suited) | 66.4% | 33.1% | 0.5% |

## Interactive Smarter.Poker Tools For This Hand
- **Simulate 66 Equity**: [Poker Odds Calculator](https://smarter.poker/tools/poker-odds-calculator?hand1=66)
- **View Full 13x13 Preflop Grid**: [GTO Preflop Range Matrix](https://smarter.poker/tools/preflop-ranges)
- **All Starting Hands**: [Starting Hand Encyclopedia](https://smarter.poker/learn/hands)